Ebola

Diskutera fysik, kemi, biologi, samt direkta tillämpningar såsom teknik och medicin.

Re: Ebola

Inläggav micke.d » fre 07 aug 2015, 21:06

Mycket goda nyheter!

En kandidat till Ebola-vaccin ser än så länge ut att vara mycket effektivt!

http://www.thelancet.com/pb/assets/raw/ ... 611175.pdf
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Re: Ebola

Inläggav Tryggve » lör 08 aug 2015, 12:47

Nature News har en del artiklar med kommentarer kring Ebolaepidemin.


Ebola: Embed research in outbreak response

Testing Ebola treatments in West Africa's epidemic happened too late. Research response during future outbreaks must be more nimble, says Trudie Lang.

http://www.nature.com/news/ebola-embed- ... se-1.18110


Denna skribent påpekar att utbrottet inte är över än.

Disease outbreak: Finish the fight against Ebola

Leaders and health agencies are talking about 'lessons learned' from West Africa's Ebola epidemic. But a major push is needed to end the outbreak, urges Joanne Liu.

http://www.nature.com/news/disease-outb ... la-1.18109


Train Africa’s scientists in crisis response
To prevent future epidemics, a new international effort must boost West Africa’s scientific and public-health capacity, says Christian Bréchot.

http://www.nature.com/news/train-africa ... se-1.18119
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Re: Ebola

Inläggav Tryggve » lör 08 aug 2015, 13:05

Nature News har för övrigt också en artikel om ebolavaccinet,


http://www.nature.com/news/how-ebola-va ... cy-1.18121

How Ebola-vaccine success could reshape clinical-trial policy

Rapid result has implications for outbreak preparedness as well as West Africa’s epidemic.

When Ebola broke out in West Africa in December 2013, triggering the largest-ever epidemic of the disease, there was no vaccine or drug that had been shown to be safe and effective in people. Just 20 months later, a vaccine seems to confer total protection against infection, according to the preliminary results of a trial in Guinea that were published on 31 July (A. M. Henao-Restrepo et al. Lancet http://dx.doi.org/10.1016/S0140-6736(15)61117-5; 2015). Nature looks at the implications of the trial’s success for the on­going epidemic, which has killed more than 11,000 people, as well as for how future clinical trials are conducted in outbreaks.
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Re: Ebola

Inläggav micke.d » tor 15 okt 2015, 23:05

Nu har två veckor gått utan några nya fall. Håller tummarna.

http://apps.who.int/ebola/current-situa ... tober-2015
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Re: Ebola

Inläggav micke.d » tor 15 okt 2015, 23:09

En brittisk sjuksköterska som fick ebola i fjol men överlevde, har nu åter insjuknat. :-(

http://www.bbc.com/news/uk-scotland-34529575
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Re: Ebola

Inläggav Tryggve » fre 16 okt 2015, 13:11

micke.d skrev:En brittisk sjuksköterska som fick ebola i fjol men överlevde, har nu åter insjuknat. :-(

http://www.bbc.com/news/uk-scotland-34529575

Oj, det var tragiskt. Jag får inte riktigt grepp exakt vad det är som är fel på henne, men det låter som om det skulle kunna vara organsvikt till följd av immunsystemets reaktion mot ebolaviruset.
Eller om det är så att virusinfektionen har blommat upp igen? Men då borde hon väl även vara smittsam?

He added: "It may be that the virus has gotten into a place where the immune system can't root it out, and that what we are seeing right now is essentially a frustrated immune system overreacting and basically hurting some of the other organs.

"We don't know what Ebola looks like the second time around or after a big relapse like this. Right now, she has had this virus about three times as long as the other previous record holder."
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Re: Ebola

Inläggav Tryggve » fre 16 okt 2015, 13:34

En av de behandlingar som utvecklats mot Ebola verkar tyvärr inte ha någon effekt vid kliniska studier.

https://en.wikipedia.org/wiki/TKM-Ebola

In January 2014, Tekmira started a Phase I clinical trial of TKM-Ebola to assess its safety in healthy people. The FDA put the trial on clinical hold in July 2014 to assess results, after some subjects had flu-like responses.[5] In August, the FDA changed the status to "partial hold", allowing the drug to be used under Expanded access in people infected with Ebola but with the Phase I trial still suspended. [1] In April 2015 the FDA allowed the study to resume at a lower dose.[6]

A Phase II trial started on 11 March 2015 and stopped enrolling new subjects on 19 June 2015 after it appeared not to work; statistical analysis was ongoing at the time.[7][8]
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Re: Ebola

Inläggav Tryggve » fre 16 okt 2015, 16:49

Nature skriver om risken för att ebola kan spridas via sperma en tid efter det att patienterna har tillfrisknat. Och beskriver i alla fall ett fall där en kvinna har smittats via samlag

http://www.nature.com/news/what-first-c ... th-1.18584

It has long been known that the Ebola virus can remain in semen for months after patients have recovered from the disease. But two studies published on 14 October in the New England Journal of Medicine1, 2 have raised concerns that sexual transmission of the virus might cause flare-ups of Ebola in West Africa after the region has been declared Ebola-free. Nature explains the implications of the findings.
What did the studies show?

One study1 recruited 93 men who had survived Ebola in Sierra Leone; they were examined between two and nine months after they first showed symptoms of the disease. Half had Ebola viral RNA in their semen. That was not a complete surprise because traces of the virus are known to linger in semen for many months. Those who first showed symptoms two months ago were most likely to test positive for the RNA. But even in the 43 people who first showed symptoms 7–9 months ago, around one-quarter still had Ebola RNA present in their semen.

The other study2 confirms the first known case of sexual transmission of Ebola, to a woman in Liberia. (A preliminary report on the same incident had been published in May).
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Re: Ebola

Inläggav micke.d » lör 02 apr 2016, 05:22

Epidemin är i stort sett över, men det förekommer små utbrott fortfarande.

http://www.bbc.com/news/health-35921161
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Re: Ebola

Inläggav Snuten92 » fre 29 apr 2016, 00:11

Nu när ebola är över är det bara att vänta in nästa sjukdom som "hotar" mänsklighetens existens XD
Ser ut som det kommer att bli ZIKA
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Re: Ebola

Inläggav matsw » fre 29 apr 2016, 04:54

Snuten92 skrev:Nu när ebola är över är det bara att vänta in nästa sjukdom som "hotar" mänsklighetens existens XD
Ser ut som det kommer att bli ZIKA


Ifrågasätter du att ebola kunnat bli en världsomfattande epidemi? Och varför gapflabbet?
det väsentliga är inte vad man vet utan hur man vet det.
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Grundforskning i utveklingsländer

Inläggav Tryggve » tor 09 jun 2016, 20:22

En artikel i Nature News som diskuterar behovet av grundforskning i utvecklingsländer. Författaren menar att det ibland ses som slöseri att länder där det finns undernäring finansierar annan forskning än sådan som ska vara direkt applicerbar på deras problem.
Ebolautbrottet är bland annat ett argument till varför denna typ av forskning behövs även i länder i Afrika, t ex.

http://www.nature.com/news/the-developi ... oo-1.20008
What use is basic science to the developing world? Why would a nation that cannot feed all its people try to send a spacecraft to Mars? Instead, scientific research in poorer nations is expected to focus on applied problems. Surrounded by poor prospects and infrastructure, institutions in these countries support fast-producing research that can provide direct results to the economy.

Much foreign investment goes the same way. For developing countries to work on pure science is often viewed from outside as indulgent and wasteful. Witness the argument that took place in the United Kingdom last year over India — a recipient of British aid — developing its own space programme.

Applied research certainly has its place, in developing as well as developed countries. Science as a tool to make money and secure a food supply is key to survival. It can target local issues: a notable success is the process developed by Brazil to turn (locally abundant) sugar cane into ethanol as a biofuel resource. In southeast Asia, the science of cassava pests and diseases is a priority, because millions of people here rely on cassava as a staple food and a source of income.

But we should not forget that there is more to life than accumulating resources. Many other factors threaten human existence — from mutating viruses to moving tectonic plates. In the Southern Hemisphere, where most developing countries are located, natural disasters and emerging diseases haunt the lives of billions of people. The Ebola epidemic and the Zika virus, the Ecuador earthquake and the Aceh tsunami are just a few recent examples. And to understand them, we do not just need science that has an economic value. We need science that questions why the world is the way it is.

Of course, some in the developing world already study pure science problems. In Indonesia, some researchers are analysing the genetics of Indonesian people and their susceptibility to certain diseases — work that also offers insights into human origins. Others are studying the ecology and evolution of non-human primates. But these efforts are dwarfed by the many government-funded projects on applied topics such as agriculture, pharmacy and animal husbandry.
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Re: Ebola

Inläggav Tryggve » fre 23 dec 2016, 12:46

En god nyhet till Jul. Ett av de vaccin som testats ska ha gett mycket gott skydd. 100% skydd enligt NY Times. Dock enbart mot en form av Ebola.

NY Times skriver om det här.

http://www.nytimes.com/2016/12/22/healt ... ccine.html

The new vaccine has some flaws, experts said. It appears to work only against one of the two most common strains of the Ebola virus, and it may not give long-lasting protection. Some of those who get it report side effects like joint pain and headaches.

“It’s certainly good news with regard to any new outbreak — and one will occur somewhere,” said Dr. Anthony S. Fauci, director of the National Institute for Allergy and Infectious Diseases, which makes many vaccines and did some early testing on this one. “But we still need to continue working on Ebola vaccines.”


Artikeln i THe Lancet.
Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)
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Re: Ebola

Inläggav micke.d » mån 29 maj 2017, 21:25

Ebola har tydligen dykt upp igen, i början av maj. Och flera har blivit smittade.

Lyckligtvis har ett vaccin nu blivit godkänt i Kongo!

http://www.eposten.se/nyheter/omvarld/k ... 64907.aspx
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Re: Ebola

Inläggav micke.d » mån 29 maj 2017, 21:30

Verkar som att risken för spridning inte är jättestor:

http://apps.who.int/iris/bitstream/1066 ... 052017.pdf

The previously undertaken modelling to determine the risk of further cases was updated with newly available onset dates for the confirmed / probable cases. Results suggest the risk of further cases is low but not negligible, and decreases with each day without new confirmed/probable cases; as of the reporting date, 67% of simulated scenarios predict no further cases in the next 30 days.
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